pntd.0009760.g006.tif (307.98 kB)
VPS38/UVRAG, ATG14 and ATG6/Beclin1 are transcriptionally regulated in the oocytes of Rhodnius prolixus.
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posted on 2021-09-07, 17:40 authored by Priscila H. Vieira, Claudia F. Benjamim, Georgia Atella, Isabela RamosOocytes dissected from silenced females were tested for the expression levels of the other class III PI3K components, and for the control genes ATG8/LC3, ATG1/ULK1, EF1 and PERK (non-related to the class III PI3K complexes). A. Expression levels of different genes in the ovaries of females silenced for VPS38/UVRAG (dsVPS38). B. Expression levels of different genes in the ovaries of females silenced for ATG14 (dsATG14). C. Expression levels of different genes in the ovaries of females silenced for ATG6/Beclin1 (dsATG6/Beclin1). Graphs show mean ± SEM. (n = 8) **p<0.01,***p<0.001. One Way ANOVA. D. Model for the transcriptional regulations between ATG6/Beclin1, VPS38/UVRAG and ATG14.
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xlink "> altogetherunviable f1 embryosrhodnius prolixus div >< ppreviously observed phenotypesdeficiency phenotypes withoutthree pi3k componentsvariant regulatory subunitssilencing effect amongyolk defective phenotypesdescribed pi3k complexesabnormal yolk organellesdeficient oocytes duevariant subunits vps38beclin1 pi3k complexespi3k subunitspi3k complexessimilar phenotypesyolk organellesdeficient oocytesyolk proteinstranscriptionally regulatedspecific silencingspecific crossreserve proteinsprevious workoocyte cortexmajor contributorgenes phenocopiedgenerating 1cross silencingchagas diseasebeclin1 resultedbeclin1 reproduced
