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VPS13C knockdown sensitized cells to proteasome inhibition.

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posted on 13.04.2016, 05:45 by Ri-Yao Yang, Huiting Xue, Lan Yu, Antonio Velayos-Baeza, Anthony P. Monaco, Fu-Tong Liu

3T3-L1 fibroblasts engineered with the doxycycline-induced LacZ or VPS13C knockdown system were treated for three days without or with doxycycline in the presence of chloroquine, MG-132, or 3-MA. Cell viability was then analyzed using MTS assay[58]. Results are representative of three experiments. Asterisks denote statistical significance.