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Treatment with rhMG53 significantly increases regeneration past the crush site.

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posted on 09.04.2020, 17:45 by Brian J. Paleo, Kathryn M. Madalena, Rohan Mital, Kevin E. McElhanon, Thomas A. Kwiatkowski, Aubrey L. Rose, Jessica K. Lerch, Noah Weisleder

A) Longitudinal sections of sciatic nerves from mice that received a crush injury and saline or rhMG53 were immunostained with SCG10. Treatment with rhMG53 increased SCG10 intensity distal to the crush site by 3 dpi. Results are expressed as mean ± SEM. Significant for treatment (***p = 0.0006) and distance (**p = 0.009) by two-way ANOVA. B, C) Treatment with rhMG53 increased the regeneration index. Results are expressed as mean ± SEM, ***p = 0.001, unpaired t test (n = 4 per group). D) Longitudinal sections of sciatic nerves from mice that received a crush injury and saline or rhMG53 were immunostained with MG53. rhMG53 treated nerves were observed to stain positive for MG53 distal to the crush site where injection occurred.

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