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Transport of DNA across brain endothelium by gold nanocarriers.

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posted on 17.09.2020, 17:30 authored by Nayab Fatima, Radka Gromnicova, Jane Loughlin, Basil Sharrack, David Male

qPCR quantitation of 40nt DNA measured in transwells treated with NP-Gal, free 40nt dsDNA, NP-DNA-40LO and NP-DNA-40HI. Tukey's multiple comparisons test was performed. The level of DNA carried across the endothelium was significantly greater with either of the NP-DNA formulations than for free DNA (**** P<0.0001) and transport by NP-DNA-40Lo was higher than NP-DNA-40Hi.