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Total CD34+KDR+ cells across pregnancy and postpartum in control, type 1 and type 2 diabetic women.

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posted on 2017-03-09, 18:35 authored by Patricia D. A. Lima, Zhilin Chen, Aysha Tayab, Malia S. Q. Murphy, Jessica Pudwell, Graeme N. Smith, B. Anne Croy

(A) Absolute numbers (per 105 mononuclear cells) of circulating CD45dimCD34+SSlowKDR+ (CD34+KDR+) cells across pregnancy and postpartum from control (i), type 1 (ii) and type 2 (iii) diabetic women. In control women, CD34+KDR+ cells were elevated in 3rd trimester and significantly higher compared to 2nd trimester (p = 0.013; i). Such fluctuation was not observed in type 1 and type 2 diabetic women (i, ii). (B) Comparisons between control (green) and type 1 (red) (i) and type 2 diabetes (black) (ii) at 1st trimester demonstrated that type 1 (p = 0.033), but not type 2 diabetic women (p = 0.090) had significantly more CD34+KDR+ CACs than control women. No differences were found when comparing control and diabetic (type 1 and type 2) women at 2nd, 3rd trimester and postpartum stages. Data in A were compared using Kruskal-Wallis test; B using Mann-Whitney test, considering p<0.05. Data in Bi and Bii were shown as a rank score graphic.

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