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Three most significant Mtb lipid matches in plasma.

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posted on 2018-10-11, 18:07 authored by Jeffrey M. Collins, Douglas I. Walker, Dean P. Jones, Nestani Tukvadze, Ken H. Liu, ViLinh T. Tran, Karan Uppal, Jennifer K. Frediani, Kirk A. Easley, Neeta Shenvi, Manoj Khadka, Eric A. Ortlund, Russell R. Kempker, Henry M. Blumberg, Thomas R. Ziegler

Intensity values of the Mtb-associated metabolites phosphatidylglycerol (PG) (16:0_18:1) and lysophosphatidylinositol (Lyso-PI) (18:0), as well as m/z 1321.9177 [each p < 0.001; active TB cases (green triangles) vs household contacts (red triangles)]. m/z 1321.9177 was predicted as acylphosphatidylinositol mannoside (Ac1PIM1) (56:1) based on accurate mass and retention time measurements, but could not be confirmed using tandem MS/MS. Line depicts median values for each subject cohort.

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