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Theoretical predictions of out-of-sample R² of the PGS, for the SNP heritability in the hold-out sample (x-axis) and the SNP heritability in the discovery samples (y-axis).

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posted on 2017-01-17, 17:41 authored by Ronald de Vlaming, Aysu Okbay, Cornelius A. Rietveld, Magnus Johannesson, Patrik K. E. Magnusson, André G. Uitterlinden, Frank J. A. van Rooij, Albert Hofman, Patrick J. F. Groenen, A. Roy Thurik, Philipp D. Koellinger

Factor levels: 50 studies, sample size 5,000 individuals per study, cross-study genetic correlation 0.8, 100k independent SNPs, and heritability arising from a subset of 1k independent SNPs.

Theoretical predictions of out-of-sample R² of the PGS, for the SNP heritability in the hold-out sample (x-axis) and the SNP heritability in the discovery samples (y-axis).

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Theoretical predictions of out-of-sample R2 of the PGS, for the SNP heritability in the hold-out sample (x-axis) and the SNP heritability in the discovery samples (y-axis).

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Keywords

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Theoretical predictions of out-of-sample R² of the PGS, for the SNP heritability in the hold-out sample (x-axis) and the SNP heritability in the discovery samples (y-axis).