The spleen pathology scale.

(A). Follicle damage: All follicles are distinct and defined in shape (score of 1, top left). A majority of follicles are distinct and defined in shape (score of 2, top middle). Approximately equal numbers of intact and damaged follicles. (score of 3, top right). The majority of follicles are damaged, with some defined follicles observed (score of 4, bottom left). All follicles are damaged (score of 5, bottom right). Scale 10um. (B) Marginal zone thickness: More than 50% of the follicles have a thick marginal zone (score of 1, left). More than 50% of the follicles have a thin marginal zone (score of 2, middle) More than 50% of the follicles do not have an observable marginal zone (score of 3, right). (C) Size of the light zone of the germinal centre: More than 50% of the follicles have a small germinal center (score of 1, left). More than 50% of the follicles have a large germinal center (score of 2, middle). More than 50% of the follicles have no observable germinal center (score of 3, right).

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