pone.0255164.g011.tif (467.5 kB)

The scheme of glutamate transport implemented in the model.

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posted on 2021-08-03, 17:27 authored by Vitaly A. Selivanov, Olga A. Zagubnaya, Yaroslav R. Nartsissov, Marta Cascante

Outside Na+ (Nao) binds to the free transporter in the ‘outer’ configuration (T), accessible for binding outside ions. This binding facilitates the binding of glutamate (Gluo) and then Na⁺ atoms again. The model assumes fast equilibrium in these steps. The transporter changes configuration (T’), facilitating dissociation of all bound Na+ ions and glutamate inside cells. K⁺ binding facilitates a switch of the transporter to the outer structure and dissociation of bound K⁺ outside.