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The role of p38 mitogen-activated protein kinase (MAPK) in human T cell effector functions

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posted on 2011-12-31, 01:48 authored by Francis Dodeller, Hendrik Schulze-Koops

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Taken from "The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells"

Arthritis Research & Therapy 2006;8(2):205-205.

Published online 17 Feb 2006


The activation of p38 MAPK in T cells downstream of the T cell receptor and CD28 is necessary for the expression of IL-10 and of the T helper type 2 (Th2) cytokines IL-4, IL-5, and IL-10, but not for that of the Th1 cytokine IFN-γ. In Th1 cells, however, p38 MAPK is involved in the expression of IL-12-induced IFN-γ production.


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