The role of p38 mitogen-activated protein kinase (MAPK) in human T cell effector functions

Copyright information:

Taken from "The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells"

Arthritis Research & Therapy 2006;8(2):205-205.

Published online 17 Feb 2006

PMCID:PMC1526596.

The activation of p38 MAPK in T cells downstream of the T cell receptor and CD28 is necessary for the expression of IL-10 and of the T helper type 2 (Th2) cytokines IL-4, IL-5, and IL-10, but not for that of the Th1 cytokine IFN-γ. In Th1 cells, however, p38 MAPK is involved in the expression of IL-12-induced IFN-γ production.