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Download fileThe proposed model by which IFN/ IL-10 pathway mediates chronic inflammation in the RA synovium by elevating NO.
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posted on 2016-09-14, 17:44 authored by Poulami Dey, Venugopal Panga, Srivatsan RaghunathanThe coloured box with the black boundary is a representative cell in the RA synovium. The Y-shaped structures are the cytokine receptors and the rectangles within the cell are protein. The black arrows indicate either activation or production. The dotted black arrow indicates an unknown mechanism of JAK2 activation.
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Gene Expression OmnibusCytokine Signalling NetworkRac 2-iNOS interactionSTATIFNInducible Nitric Oxide Synthase ExpressionGEOsynovial macrophagesRACnetwork genesregulationenzyme inducible nitric oxide synthaseIL -10 pathwaysRA synoviumprotein ras-related C 3 botulinum toxin substrate 2TGFtranscription factor signal transducers
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