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The close resemblance between GWAS results and linear sensitivity analysis.

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posted on 05.04.2012, 02:03 by Yunpeng Wang, Arne B. Gjuvsland, Jon Olav Vik, Nicolas P. Smith, Peter J. Hunter, Stig W. Omholt

(A) The number of causative SNPs for each parameter(y axis) detected by performing GWAS on high-level cellular phenotypes(x axis). The color intensity of each square describes the mean value of 100 Monte Carlo runs. (B) Sensitivities of the high-level phenotypes (x axis) of the 2500 individuals in the training set to variation in each parameter (y axis) quantified by univariate linear regression (see Methods). The color intensity of each square describes the mean R2 (coefficient of determination) value of 100 Monte Carlo runs.

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