The RIO family of kinases are evolutionary conserved.
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posted on 2015-02-17, 03:24 authored by Tasha K. Mendes, Stevan Novakovic, Greta Raymant, Sonja E. Bertram, Reza Esmaillie, Saravanapriah Nadarajan, Bert Breugelmans, Andreas Hofmann, Robin B. Gasser, Monica P. Colaiácovo, Peter R. Boag(A) Unrooted phylogenetic tree of RIO proteins derived from a Clustal Omega alignment of whole proteins sequences (European Bioinformatics Institute). Tree was drawn using Philodendron Phylogenetic tree printer. Hs, H. sapiens; Mm, M. musculus; Dm, melanogaster; Ce, C. elegans; Xl, X. Laevis; Dr, D. reri; Dd, D. discoideum; At, A. thaliana; Sc, S. cerevisiae (B) Schematic representing the domain organisation in RIO kinases. Each of the RIO kinase sub-families has a conserved domain organisation; Hs, H. sapiens; Dm, melanogaster; Ce, C. elegans; Sc, S. cerevisiae examined. (C) Alignment of the ATP binding loop in the RIO domain.
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cell cycle controlgermline defectsbinding sitesriokSKNoocyte maturationgene encoding RIOKgerm lineCaenorhabditis elegans RIO protein kinasespost mitotic tissuesRIO Protein Kinasesgenes codingelegans genomeRNA processingCell proliferationmulticellular organismsendomitotic oocytesTissue Expression Pattern
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