Tamiflu Synthesis - 3

Continuing with the modifications of the original machine proposed 6 step total synthesis of Tamiflu, we're putting up yet another synthesis derived from the original disconnections. 

 

This synthesis accomplishes the synthesis of Tamiflu from a simple COOH derivative of oxo-cyclohexadiene in a total of 5 steps, with 3 in the longest linear sequence.

 

The stereochemistry for the alcohol is proposed to be set via a chiral reduction.

 

As stated in the other articles, we've spent a considerable amount of time training the software to look for the most efficient and customizable disconnection points, and thus far we feel that we are making great progress in that area, as the proposed syntheses we've presented suggest. The software has also improved with the selection of novel reactions, the suggestion of reaction conditions, and the prediciton of trajetories/chelation events/coordination, etc.

 

For more information on this project please send an email to Jamie@ITSMolecularDesign.com.