pntd.0006487.g002.tif (96.71 kB)

Synthetic route to putative hit compounds.

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posted on 11.07.2018 by Frederick A. Partridge, Ruth Forman, Nicky J. Willis, Carole J. R. Bataille, Emma A. Murphy, Anwen E. Brown, Narinder Heyer-Chauhan, Bruno Marinič, Daniel J. C. Sowood, Graham M. Wynne, Kathryn J. Else, Angela J. Russell, David B. Sattelle

(a) Substituted 2-phenoxyethan-1-amine (1.0 equiv.), DIPEA (2.0 equiv.), 1,4-dioxane, 80°C, 3 hours. (b) Alkyl amine (10.0 equiv.), iPrOH, 100°C, 16–24 hours.

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