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Synthesis and characterization of drug-delivery nanoparticles.

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posted on 03.04.2017, 17:52 by R. Doug Wagner, Shemedia J. Johnson, Zhixia Yan Danielsen, Jin-Hee Lim, Thilak Mudalige, Sean Linder

(a) Structure of PLGA-PEG diblock copolymer for construction of 116 nm particles and 1H-NMR analysis of synthesized nanoparticles. The scan shows lactide methine quartets at 5.2 ppm (peak A), lactide methyl doublets at 1.5 ppm (peak B), glycolide proton singlets at 4.9 ppm (peak C), and polyethylene glycol methylene singlets at 3.5 ppm (peak D) characteristic of PLGA-PEG. (b) Scanning electron micrograph of PLGA-PEG nanoparticles. (c) Scanning electron micrograph of graphene oxide–polyethylene glycol nanoparticles. (d) Size distribution of PLGA-PEG nanoparticles determined by transmission electron microscopy.

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