Supplemental Files Ogoniak et al. 2025

Supplemental Figure S1 - Flow Diagram of Cohort Distribution for GWAS and PGS Analysis of Baseline Biomarker Levels

Supplemental Figure S2 - PGS_BAT application in follow-up cohort: The developed PGS_BAT plotted against the BAT values at baseline in the follow-up cohort (A). The cross-trait application to the relative BAT difference in the follow-up cohort (B). Individual measurements are indicated by dots while colors indicate age at baseline.

Supplemental Figure S3 - Manhattan plots for hormone differences between baseline and follow-up: GWAS results for T (A), BAT (B) and SHBG (C) for relative hormone level difference in the follow-up cohort. Dashed line represents genome-wide significance level (p = 5x10^-8)

Supplemental Figure S4 - Relative BAT difference tertiles: The follow-up cohort was divided to tertiles according to relative BAT difference. Individual measurements are indicated by dots while colors indicate age at baseline. The grey shaded area indicates declining levels in BAT levels between baseline and follow-up.