Summary scheme of the theoretically calculated antitumor activity of the biologically modified amygdalin and the site of the dosage form throughout the biochemical cycle

article - DOI: 10.2174/1871520620666200313163801
monograph - DOI: 10.5281/zenodo.7295357 | ISBN: 978-619-91534-4-4
ATLAS - presentation of the finale information in the most applied and convenient form of application - DOI: 10.5281/zenodo.8009390 | ISBN: 978-619-91534-5-1

...The hydrolyzed to amide / carboxylic acid cyano / nitrile glycosides are potential drugs. Their biological activity remains unchanged, but their toxicity is many times lower than unmodified native molecules. The amygdalin / dhurrin-derived amide is only one of the dozens of studies we have conducted and we make this claim.

We conditionally divide the bio-activity into three conditional sub-schemes:

Molecular Transition I: In the stomach under the action of hydrochloric acid and coordination-unrelated cobalt (I.), i. in the form of an ion, hydrolysis occurs by acid catalysis. For the retention of cobalt ions in the stomach long enough and with the necessary concentration during the diet, we have theoretically derived the most probable and physiologically justified reaction, namely in the form of cobalt oxalates. The corresponding amide is obtained. The same end product can also be obtained in an in-vitro environment using enzymes. Regardless of the method and place of production, an already modified molecule of amygdalin enters the bloodstream;

Molecular Transition II: In the blood under the action of beta-glucosidases[1] and water (reaction #1), begins to break down glycosidic bonds and secrete free glycosides and Linamarine amide derivative. It undergoes Amygdalin beta-glucosidase in mandelamide (reaction #2). The remaining free glycosides and a small fraction of the amide derivative of amydalin are also attacked by Glucose oxidases (reaction #3). Glucono delta-lactone is obtained which under the action of water is converted to gluconic acid (reaction #4). It is important to note that with an increase in the concentration of glucono delta-lactone above 1mMol / ml, inhibition of the activity of amygdalin beta-glucosidase also occurs (reaction #5). The presence of such active molecules at this stage also results in increased biological activity and by-products of the reaction.

Molecular Transition III: Based on an author's study on the achievements in the anti-tumor mechanism of Amygdalin and when standard living organisms are set, six molecular forms (III. A, BH3, C, AC, BC, CC) are clearly distinguished, and they are thought to exhibit anti-tumor activity. Based on the paragraph four that it will be at least the same as in the clinical trials of pure Amygdalin....

[1] To take into account the possible presence of a concomitant disease of the patient - such as diabetes, impaired renal function, etc., which would decrease the concentration in the human blood.