Subgroup analyses according to sex and age.

Fig A: Among men, the numbers of participants with low FRS, intermediate FRS, high FRS, and prevalent CVD were 3,325 (51.7%), 1,187 (18.5%), 1,676 (26.1%), and 244 (3.7%) in the Non-PO group; 1,070 (30.9%), 851 (24.5%), 1,363 (39.3%), and 183 (5.3%) in the NS-PO group; and 278 (21.5%), 335 (25.9%), 578 (44.8%), and 100 (7.8%) in the Severe PO group, respectively (P < 0.001). Among women, the numbers of participants with low FRS, intermediate FRS, high FRS, and prevalent CVD were 8,893 (82.3%), 1,203 (11.1%), 411 (3.8%), and 298 (2.8%) in the Non-PO group; 2,213 (67.7%), 647 (19.8%), 264 (8.1%), and 147 (4.4%) in the NS-PO group; and 485 (58.3%), 205 (24.7%), 89 (10.7%), and 52 (6.3%) in the Severe PO group, respectively (P < 0.001). Fig B: Among participants < 65 years old, the numbers with low FRS, intermediate FRS, high FRS, and prevalent CVD were 11,741 (79.6%), 1,696 (11.5%), 1,038 (7.0%), and 276 (1.9%) in the Non-PO group; 3,007 (58.9%), 1,103 (21.6%), 839 (16.4%), and 156 (3.1%) in the NS-PO group; and 724 (45.2%), 431 (27.0%), 368 (23.0%), and 76 (4.8%) in the Severe PO group, respectively (P < 0.001). Among participants ≥ 65 years old, the numbers with low FRS, intermediate FRS, high FRS, and prevalent CVD were 477 (19.2%), 694 (27.9%), 1,049 (42.2%), and 266 (10.7%) in the Non-PO group; 276 (16.9%), 395 (24.2%), 788 (48.3%), and 174 (10.6%) in the NS-PO group; and 39 (7.5%), 109 (20.8%), 299 (57.2%), and 76 (14.5%) in the Severe PO group, respectively (P <0.001). Abbreviations: FRS, Framingham risk score; CVD, cardiovascular disease; Non-PO, participants without periodontitis; NS-PO, participants with non-severe periodontitis; Severe PO, participants with severe periodontitis.