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Structure-based discovery of inhibitors of the YycG histidine kinase: New chemical leads to combat infections-6

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posted on 2011-12-31, 02:59 authored by Zhiqiang Qin, Jian Zhang, Bin Xu, Lili Chen, Yang Wu, Xiaomei Yang, Xu Shen, Soeren Molin, Antoine Danchin, Hualiang Jiang, Di Qu

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Taken from "Structure-based discovery of inhibitors of the YycG histidine kinase: New chemical leads to combat infections"

BMC Microbiology 2006;6():96-96.

Published online 10 Nov 2006

PMCID:PMC1660542.

ompound (6.25 μM), compound (100 μM), and compound (0.2 μM), respectively. The MICs of Tet and Cip are both 0.25 μg/ml. Each assay was performed in quadruplicate and repeated twice. The values represented the mean and SD from one separate experiment. Cells with no compounds treatment and with 1% Triton-100 treatment were for the zero and 100% hemolysis controls, respectively. Black and white columns represented the concentrations of 4×MICs and MICs of 7 inhibitors and two conventional antibiotics, respectively. Tet: tetracycline, Cip: ciprofloxacin.