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Spastin depletion modifies lipid profile in adult zebrafish brain and skeletal muscle.

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posted on 21.04.2020 by Yoan Arribat, Dogan Grepper, Sylviane Lagarrigue, Timothy Qi, Sarah Cohen, Francesca Amati

(A-B) Unesterified cholesterol (Chol), total esterified cholesterol (Est Chol) and total triacylglycerides (Tot TG) in brain (A) and in muscle (B). (C) Fatty acids composed of C16 in muscle. (D-E) Ceramides (Cer) in brain (D) and muscle (E). (F) Phosphatidylethanoamines (PE) in brain. All values correspond to lipid quantity per total protein amount. Bars are mean ± SEM (n = 3 per group), #P<0.08, *P<0.05, P<0.01, ***P<0.001 (unpaired t‐test between Ctrl and Spa-/-). See also S1 Table.