Spastin depletion modifies lipid profile in adult zebrafish brain and skeletal muscle.
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posted on 2020-04-21, 22:05 authored by Yoan Arribat, Dogan Grepper, Sylviane Lagarrigue, Timothy Qi, Sarah Cohen, Francesca Amati<p>(A-B) Unesterified cholesterol (Chol), total esterified cholesterol (Est Chol) and total triacylglycerides (Tot TG) in brain (A) and in muscle (B). (C) Fatty acids composed of C16 in muscle. (D-E) Ceramides (Cer) in brain (D) and muscle (E). (F) Phosphatidylethanoamines (PE) in brain. All values correspond to lipid quantity per total protein amount. Bars are mean ± SEM (n = 3 per group), #<i>P</i><0.08, *<i>P</i><0.05, <i>P</i><0.01, ***P<0.001 (unpaired <i>t</i>‐test between Ctrl and Spa-/-). See also <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008665#pgen.1008665.s005" target="_blank">S1 Table</a>.</p>
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Spastin depletionresults showHSPSpastin M 1Spastin mutationsnovel biomarkersorganelle componentssystem resultsintracellular dispersionlipid droplet dispersionorganelle dynamicsHereditary Spastic ParaplegiaMTcoordinates LD dispersionSpastin modulates transcripts levelsm 1 isoformssplice variantsendoplasmic reticulumreticulum Lipid dropletsREEP 1.ER shapeimpacts lipids profileimpact LD fatesubcellular locationSpastin depletion influencesLD dispersionimpacts LD network
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