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Smoking history is associated with CENPA, FOXM1, and MYBL2 expression in TCGA samples.

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posted on 14.09.2020, 17:41 by Daniel J. Mullen, Chunli Yan, Diane S. Kang, Beiyun Zhou, Zea Borok, Crystal N. Marconett, Peggy J. Farnham, Ite A. Offringa, Suhn Kyong Rhie

(A) Boxplots of CENPA, FOXM1, and MYBL2 expression in 453 TCGA LUAD tumor samples stratified by smoking history. Tumor samples from current smokers had significantly higher expression of all three transcriptional regulator genes than those from former smokers and individuals who had never smoked (significant Tukey HSD p-values displayed; ***p<0.005). (B) Boxplots show CENPA, FOXM1, and MYBL2 expression in all 453 TCGA LUAD tumor samples stratified by median total mutational count. Samples with higher mutational burden had higher expression of these transcriptional regulators.

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