Single-nucleus transcriptomic analysis on the glial cells in the hippocampus of <i>Cyfip2</i><sup><i>+/R87C</i></sup> mice.

https://doi.org/10.1371/journal.pbio.3003192.s016
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posted on 2025-10-09, 18:20 authored by Ruiying Ma, Muwon Kang, Gyu Hyun Kim, Hyojin Kang, Sunho Lee, Yeji Yang, Hea Ji Lee, Seungji Choi, Seungsoo Kim, Seoyeong Kim, Yukyung Jun, Hyewon Kim, Yinhua Zhang, U Suk Kim, Hyae Rim Kang, Yoonhee Kim, Yulim Lee, Woosuk Chung, Eun Jung Lee, Serk In Park, Eunha Kim, Minji Jeon, Geum-Sook Hwang, Jungmin Choi, Youngae Jung, Jin Young Kim, Eunjoon Kim, Kea Joo Lee, Kihoon Han

<p><b>(A)</b> Subclustering results of oligodendrocytes. The left panel presents a UMAP visualization of oligodendrocyte subtypes, while the right panel features a dot plot highlighting the top DEGs for each cluster. <b>(B)</b> Subclustering results of microglia. The left panel presents a UMAP visualization of microglia subtypes, while the right panel features a dot plot highlighting the top DEGs for each cluster.</p> <p>(TIF)</p>

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uncover underlying mechanisms spontaneous recurrent seizures recent genetic studies recapitulate key symptoms many patients progress gain deeper insight cell level transcriptomics lipid droplet accumulation early pediatric symptoms >/ r87c </west syndrome patients tracked seizure activity mouse model carrying dependent synapse remodeling >< sup >+<including infantile spasms div >< p west syndrome mouse model infantile spasms synaptic remodeling lipid metabolism including tissue early symptom dependent interactions cyfip2 </neonatal spasms ultrastructural analysis ultimately leading typically subsides term outcomes significant proteomic seven months sequential activation seizure forms seizure evolution results showed premature death omic approaches omic analyses neurodevelopmental disorders neonatal stage mice entered longitudinal multi lipidomic changes lasting effects initial period glial cells free phase findings suggest

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