Simulation results predict the role of AC in driving the in-phase behavior and decreasing time delay for inversely out-of-phase behavior.

(A-C) The dynamics of Ca²⁺ and cAMP at different locations when the AC level is varied. The AC concentration is 75% (A), 50% (B), and 25% (C) of the original value. (D) The in-phase and inversely out-of-phase cAMP behavior in (A-C). (E) The time delay of peaks between Ca²⁺ and cAMP as a function of the distance x in (A-B). The x has the same definition as that in Fig 2B.