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Simulation output from a Boolean model of the pair-rule network.

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posted on 2017-09-27, 17:25 authored by Erik Clark

Pair-rule gene expression patterns generated by simulating a Boolean model of the pair-rule network, assuming static “gap” inputs (A), dynamic “gap” inputs (B), or dynamic “gap” inputs and no Eve expression (C). Original simulations are shown in S9S11 Movies. In each panel, the horizontal axis represents the anteroposterior (AP) axis (anterior left), while the vertical axis represents the different gene products that might be expressed in a given “cell” (column). Pale colours represent active transcription; dark colours represent active protein (see colour key at top right). Grey vertical lines indicate the span of an idealised double-segment repeat of 8 “cells”. The same 7 time points (T20–T56) are shown for each simulation. Cad turns off between the first (T20) and second (T26) panels (dashed lines), derepressing prd and slp. Opa turns on between the third (T32) and fourth (T38) panels (dashed lines), causing a switch from the early to the late network logic. Parasegment boundaries (black vertical lines at T56, located between abutting domains of Slp and En) are only produced by the simulation with dynamic gap inputs (B). Abbreviations: Cad, Caudal; Opa, Odd-paired; prd, paired; slp, sloppy-paired.

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