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Simulation of the potential effectiveness of post-treatment chemoprophylaxis with weekly chloroquine (CQ) to prevent P. vivax recurrences after a primary infection.

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posted on 31.07.2020, 17:43 by Rodrigo M. Corder, Antonio C. P. de Lima, David S. Khoury, Steffen S. Docken, Miles P. Davenport, Marcelo U. Ferreira

We considered scenarios with CQ prophylaxis being given over 4 (panels A, B and C), 8 (panels D, E and F) or 12 (panels G, H and I) weeks, being able to suppress 60% (panels A, D and G), 80% (panels B, E and H) or 100% (panels C, F and I) of blood-stage infections (regardless of its origin, whether hypnozoite- or mosquito bite-derived) during the period of administration. Dashed lines (“Ref.”) represent the scenario without intervention; the dark grey area represents the cumulative proportion of subjects with P. vivax relapses/recrudescences over time and the light grey area represents the cumulative proportion of subjects with new P. vivax infections.

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