Severe runting and a shortened life-span of Traf7fl/fl mice with serendipitous deletion in 2310061I04Rik gene (Traf7fl*/fl*).
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posted on 2024-12-04, 21:02 authored by Erdyni N. Tsitsikov, Khanh P. Phan, Yufeng Liu, Alla V. Tsytsykova, Rosalia Paterno, David M. Sherry, Anthony C. Johnson, Ian F. Dunn(A) Mouse weight chart from P13 to end of life of Traf7fl*/fl* mice. (n = 391 (1–20 animals) WT, n = 481 (1–30 animals) Traf7+/fl*, n = 230 (1–15 animals) Traf7fl*/fl*). Data presented as median±SEM. (B) Representative 4-weeks old WT and Traf7fl*/fl* littermates. (C) Probability of survival of Traf7fl*/fl* mice. n = 25 Traf7fl*/fl*.
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unknown function locatedpostnatal day 24div >< pdisplayed extensive vacuolationappeared anatomically normalspontaneous mouse mutant>< sup ><impaired brain myelinationspontaneous mutationalso impaired>two weekstranscriptome analysistaken togetherp24 ).oligodendrocyte maturationnull nd4 nd2 mitochondrial geneshistological examinationglycoprotein expressedgenes specificfirst introndifferentiated oligodendrocytesdied shortlycytb co1 chromosome 17brains comparedborn healthyatp6 ataxic gaitanteroventral nucleianterodorsal nucleianterior commissure2310061i04rik
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