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Sensitivity analysis was performed on the fixed elimination rate model ( and ) and the inducible elimination rate model ( and )

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posted on 31.12.2011, 02:38 by Claude Emond, Linda S. Birnbaum, Michael J. DeVito

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Taken from "Use of a Physiologically Based Pharmacokinetic Model for Rats to Study the Influence of Body Fat Mass and Induction of CYP1A2 on the Pharmacokinetics of TCDD"

Environmental Health Perspectives 2006;114(9):1394-1400.

Published online 18 Apr 2006


This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI

The analysis was performed at 0.001 μg/kg ( and ) and at 10 μg/kg ( and ). Abbreviations: BW_T0, body weight at time zero (other parameter symbols are defined in ); var, variation. This sensitivity recorded the percentage of variation (≥ 2%) of TCDD concentrations in the blood compartment when parameters were varied by ±10%.


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