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Sensitivity analysis: Standardized PRSBMI values in carriers and noncarriers of normal weight versus obesity after excluding rs1367004987, Affx-89021050, and rs775382722 from the high-impact variants.

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posted on 2020-07-21, 17:23 authored by Nathalie Chami, Michael Preuss, Ryan W. Walker, Arden Moscati, Ruth J. F. Loos

PRSBMI, polygenic risk score for BMI.

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The role of polygenic susceptibility to obesity among carriers of pathogenic mutations in MC4R in the UK Biobank population
PLOS MedicinePLOS Medicine

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MC 4R mutationsUK Biobank population Background Me...body weight regulationbody mass indexobesityHuman Gene Mutation Databasebody weight11 mutationsgenome-wide polygenic risk scoreUK Biobank populationcase-focused studiespopulation-based cohort studyMC 4Rcarriercontrol body weightage 10 yearsHGMDSEPRS BMISDS1.7- m-tall personMC 4R deficiency

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