Selective immune response of blood group O individuals to increased enteral absorption.

Spontaneous variations in the production of anti-A/B isoagglutinins in 21 individuals suffering from ulcerative colitis (blood group A = 11, blood group 0 = 10), and in 42 normal persons (blood group A = 22, blood group O = 20), are investigated under double-blind conditions. The grade of immunization and dominance of the 7S (IgG) conglutinating and 19S (IgM) agglutinating immunoglobulins are determined through conglutinin and agglutinin titers and their quotients at three different temperatures. Using the non-parametric Wilcoxon procedure, the minimally elevated anti-B-reactive IgG and IgM levels in blood group A plasma remain within normal range, whereas the blood group O patients show a statistically significant stimulation of an IgG conglutinating and IgM agglutinating anti-B, involving asymmetrically cross-reactive, less pronounced anti-A specific IgG, and the IgG/IgM quotients indicate a predominance of the IgG class. The figure is reconstructed from the data published in: Arend, P. & Fehlhaber, G. Varying influence of increased enteral antigen absorption on the behavior of “natural” antibodies in O and A blood group subjects. Comparative blood group serological studies on patients with ulcerative colitis and healthy persons [Article in German]. J Mol Med (Klinische Wochenschrift). 1969; 47 535-541, (2), doi:10.1007/BF01715818