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Schematic showing how 20E induces autophagy and apoptosis in the tick salivary glands.

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posted on 2021-01-29, 18:47 authored by Yanan Wang, Houshuang Zhang, Li Luo, Yongzhi Zhou, Jie Cao, Xuenan Xuan, Hiroshi Suzuki, Jinlin Zhou

At low concentrations (during the slow-feeding phase, days 1–4 of feeding) 20E induces autophagy. As the concentration of 20E increases (during the fast-feeding phase, days 5–7 of feeding), cellular Ca2+ increases, mediating the cleavage of RhATG5, and thus the transition from autophagy to apoptosis.