Schematic representation of the descriptive dependences of the interpretable prognosis of susceptibility to active pharmaceutical forms for oral use and their corresponding active anti-cancer molecules (obtained after passage through the cell membrane), based on amides/carboxylic acids - hydrolysis derivatives of natural nitrile glycosides, of transcriptome cell lines inherent in tumors

excerpt from an edition:

A T L A S - Interpretable prognosis for susceptibility to active anti-cancer molecular forms, based on amides/carboxylic acids - hydrolysis derivatives of natural nitrile glycosides, of transcriptome cell lines inherent in tumors /Second supplemented edition/ - DOI: 10.5281/zenodo.13777292 | ISBN: 978-619-91534-6-8

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In this figure present the descriptive dependences of the interpretable predictions of susceptibility to active anti-cancer molecular forms of transcriptional cell lines inherent in tumors of different nature.

They highlight some molecular forms that are extremely active.

These are:

for basic pharmaceutical forms /sorted by total activity/:

(R)-2-methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)butanamide and .../butanoic acid in stoichiometric ratio by mass 4.87:1 is released inside the cancer cell (R)-2-hydroxy-2-methylbutanamide and .../butanoic acid ,

((2R,3S,4S,5R,6R)-6-(((2R,3S)-4-amino-3-methyl-4-oxobutan-2-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methyl (2S,3R)-2-ethyl-2,3-dihydroxybutanoate and (2S,3R)-3-(((2R,3R,4S,5S,6R)-6-((((2S,3R)-2-ethyl-2,3-dihydroxybutanoyl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-2-methylbutanoic acid in stoichiometric ratio by mass 4.87:1 is released inside the cancer cell (2S,3R)-3-hydroxy-2-methylbutanamide and .../butanoic acid ,

2-methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)propanamide and .../propanoic acid in stoichiometric ratio by mass 4.87:1 is released inside the cancer cell 2-hydroxy-2-methylpropanamide and .../propanoic acid ,

(Z)-2-((2S,3R,4S,6R)-2,3-dihydroxy-4-methoxy-6-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)cyclohexylidene)acetamide and .../acetic acid in stoichiometric ratio by mass 4.87:1 is released inside the cancer cell (E)-2-((2S,3R,4S,6R)-2,3,6-trihydroxy-4-methoxycyclohexylidene)acetamide and .../acetic acid ,

(2S,3R)-2-hydroxy-4-methoxy-1-methyl-6-oxo-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,2,3,6-tetrahydropyridine-3-carboxamide and .../carboxylic acid in stoichiometric ratio by mass 4.87:1 is released inside the cancer cell (2S,3R)-2,3-dihydroxy-4-methoxy-1-methyl-6-oxo-1,2,3,6-tetrahydropyridine-3-carboxamide and .../carboxylic acid ,

the rest ACCF can be found in the file and the ATLAS ;

for substitute forms:

2-((S)-2-oxo-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,3-dihydrobenzofuran-3-yl)acetamide and .../acetic acid in stoichiometric ratio by mass 4.87:1 is released inside the cancer cell (S)-2-(3-hydroxy-2-oxo-2,3-dihydrobenzofuran-3-yl)acetamide and .../acetic acid ,

(R)-2-phenyl-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)acetamide and .../acetic acid in stoichiometric ratio by mass 4.87:1 is released inside the cancer cell (R)-2-hydroxy-2-phenylacetamide and .../acetic acid ,

(2R,3R,4S,5R,6R)-2-(((Z)-4-amino-2-methyl-4-oxobut-2-en-1-yl)oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl acetate and (Z)-4-(((2R,3R,4S,5R,6R)-4-acetoxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-methylbut-2-enoic acid in stoichiometric ratio by mass 4.87:1 is released inside the cancer cell (Z)-4-hydroxy-3-methylbut-2-enamide and .../enoic acid ,

the rest ACCF can be found in the file and the ATLAS.

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