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Schematic illustration of endothelial cell transitions.

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posted on 2020-04-10, 17:30 authored by Caleb M. Phillips, Ernesto A. B. F. Lima, Ryan T. Woodall, Amy Brock, Thomas E. Yankeelov

The arrows show the transitions that each endothelial cell phenotype may experience. Phalanx cells (E) may transition to tip cells if the concentration of VEGF is greater than a threshold αV and is greater than dES away from the closest tip cell (T) or to a stalk cell (S) if the distance to an activated tip cell is less than dSE. Stalk cells may divide after time τSP and then have a growing period τgs.