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Download fileRunx3 overexpression rescues the cbfb mutant phenotypes in TG.
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posted on 2017-07-14, 17:28 authored by Philia Gau, Andrew Curtright, Logan Condon, David W. Raible, Ajay DhakaA-D, Antibody staining for GFP of TG in cbfb-/- trpa1b:GFP mutants injected with 0 or 400pg of runx3 RNA at 3dpf. E-F TrkB1 colormetric in situ hybridization staining for GFP in cbfbw128/w128; trpa1b:GFP mutants injected with 0 or 400pg of runx3 RNA at 3dpf. I-L TrkC1 colormetric in situ hybridization staining for GFP in cbfbw128/x128; trpa1b:GFP mutants injected with 0 or 400pg of runx3 RNA at 3dpf.
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neurotrophin receptor expressionTrkB expressionvertebrates marksignal amplifierneurotrophin receptorssomatosensory neuron typesfate determinationobligate cofactorneuron cell fate determinationnociceptor diversificationteleost fishneurotrophin receptor codeRunx protein stabilityRunx activityDNARunx 1 mediates TrkATrkC expressionRunx 3Runx transcription factorsneurotrophin receptorsomatosensory neuron fate specificationreceptor expressionHigh levelszebrafish Runx 3zebrafish larvaefate specification
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