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Role of reactive oxygen species (ROS) in CORM-A1 modulation of neuronal differentiation.

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posted on 04.05.2016 by Ana S. Almeida, Nuno L. Soares, Melissa Vieira, Jan Bert Gramsbergen, Helena L. A. Vieira

(A) Quantification of intracellular ROS in NT2 mixed cell populations after 24 days of neuronal differentiation (values normalized by total cell count); (B) Intracellular ROS quantification in SH-SY5Y mixed population 1h after treatment with RA 10μM ± CORM-A1 25μM and after 7 days of differentiation (values normalized by total cell count); (C) Phase contrast images of SH-SY5Y cells after 7 days of differentiation under different conditions (including N-acetylcysteine treatment); (D) Quantification of cell number and protein levels of SH-SY5Y cells after 7 days of differentiation under different conditions.

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