Retinal function in SIRT6 deficient mice.
Scotopic (A-F) and photopic (G, H) full-field electroretinography (ERG) recordings may suggest accelerated aging in KO eyes. At one month of age, dark-adapted ERG responses to a series of increasing white flash intensities showed preserved a-wave amplitudes in KO as compared to WT and HET eyes (A), while a trend towards lower amplitudes was observed in the scotopic b-wave amplitudes, attaining statistical significance at 3 high intensities (B). At the age of 6 months, scotopic a-wave responses at higher intensities showed a trend towards lower amplitudes (C), and b-wave amplitudes were markedly reduced (D). At 10 months, both a- and b-wave amplitudes in KO mice were markedly reduced as compared to WT and HET mice (E, F). Light adapted 16Hz flicker responses were also markedly reduced in KO mice at 6 and 10 months (G, H). ERG responses were similar in WT and HET mice at all ages. Results are presented as mean ± SEM; n = 6–9 for WT, n = 7–8 for HET, and n = 4–5 for KO mice. * P < 0.05.