pgen.1009534.g004.tif (1.95 MB)

Results of power analysis across 29 simulated SNP-SNP interaction models.

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posted on 2021-06-04, 18:28 authored by Molly A. Hall, John Wallace, Anastasia M. Lucas, Yuki Bradford, Shefali S. Verma, Bertram Müller-Myhsok, Kristin Passero, Jiayan Zhou, John McGuigan, Beibei Jiang, Sarah A. Pendergrass, Yanfei Zhang, Peggy Peissig, Murray Brilliant, Patrick Sleiman, Hakon Hakonarson, John B. Harley, Krzysztof Kiryluk, Kristel Van Steen, Jason H. Moore, Marylyn D. Ritchie

Power was calculated as the percentage of simulated models (out of 1,000 datasets for each model) for which the encoding detected an interaction signal at LRT p-value < 0.05: additive (red circle), dominant (yellow square), recessive (green diamond), codominant (blue triangle), and EDGE (purple inverted triangle). Twenty-nine SNP-SNP interaction models were simulated. Above the solid horizontal line are interaction models with comprehensive two-SNP combinations between SNPs with REC, SUB, ADD, SUP, and DOM action (between the solid and dotted line are models including SNPs with HET action). Below the solid horizontal line are genotype-based interaction models. The blue and red vertical lines marks 5% and 80% power, respectively.