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Representative TI = 6000 ms image, lung density (S0air), R1air, R1O2 maps of a control and PPE-challenged mouse lung.

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posted on 15.03.2016, 00:25 by Magdalena Zurek, Louise Sladen, Edvin Johansson, Marita Olsson, Sonya Jackson, Hui Zhang, Gaell Mayer, Paul D. Hockings

The maps are overlaid on TI = 6000 ms image acquired when animals were breathing air (a). ΔR1 (oxygen uptake), ΔR2* (oxygen delivery) maps for the same control and a PPE-challenged mouse (b). The challenged mouse exhibits less uniform distributions of ΔR1 and ΔR2* suggesting that the oxygen uptake and delivery to the lung were more heterogeneous. Regions of spatially matched ΔR1 and ΔR2* are indicated by arrows. Mean ΔR1 assessed in 20 bins based on ΔR2* for control (open squares) and PPE-challenged (filled squares) mice, showing excellent correlation between ΔR1 and ΔR2* (c).