Repertoire diversity in a complementary healthy control cohort.
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posted on 2023-02-24, 19:07 authored by María Ruiz Ortega, Natanael Spisak, Thierry Mora, Aleksandra M. WalczakValues of the selection parameter q as a function of age in repertoires of an independent cohort from [31]. Again, diversity significantly (p<0.001) decreases in repertoires of older people, supporting the idea that aging is accompanied by a loss of repertoire diversity, with the exception of individuals of age 75+.
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random generation processmodel underestimates sharingknown viral specificitycommon functional selectionaccurate diagnostic toolusing probabilistic modelingdriven convergent selectioncell receptor repertoirespublic receptors sharedpublic receptorscell membraneswide vaccinessuccess reliesshow manysequence featuresprotein receptorspreviously reportednetwork organizationindividuals infectedidentify coviddeveloping populationassociated receptors
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