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Removing highly active neurons predominantly alters oscillation dynamics.

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posted on 23.09.2020, 17:34 authored by David Gabrieli, Samantha N. Schumm, Nicholas F. Vigilante, Brandon Parvesse, David F. Meaney

(A) Raster plots before injury, at 50% high firing rate (HFR) excitatory neuron injury, and after network restructuring with STDP. (B) Network activity did not significantly vary from baseline after HFR neurodegeneration. (C-D) Oscillation frequency and magnitude after plasticity were significantly different at the same injury level at higher levels of injury. (E) Oscillation width increased above baseline levels after damage and was maintained following restructuring with STDP.