Relative risks of the new mutations with regards to known RAMs on the African dataset.

(i.e. the prevalence of the new mutation in sequences with a given RAM divided by the prevalence of the new mutation in sequences without the RAM). RRs were only computed for mutations (new and RAMs) that appeared in at least 30 sequences, which is why RRs were not computed for H208Y and D218E. 95% confidence intervals, represented by vertical bars, were computed with 1000 bootstrap samples of the African sequences. Only RRs with a lower CI boundary greater than 2 are shown. The shape and color of the point represents the type of RAM as defined by Stanford’s HIVDB. Blue circle: NRTI, orange square: NNRTI, green diamond: Other. For the RR of L228H with regards to M184V, the upper CI bound is infinite. The new RAMs have high RR values for known RAMs similar to those obtained on the UK dataset. We also arrive at similar conclusions, I135L being associated with NNRTIs, E203K and L228H to NRTI and L228R to both. RR values are shown from left to right, by order of decreasing values on the lower bound of the 95% CI.

(EPS)