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Relationship between splicing and D10 targeting.

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posted on 24.02.2022, 18:43 authored by Michael Ly, Hannah M. Burgess, Sahil B. Shah, Ian Mohr, Britt A. Glaunsinger

(A) Cellular transcripts were divided into intron-containing or intronless category and plotted against their fold-change value upon D10 induction. ****P≤0.0001, Mann-Whitney test. The whiskers represent the 10th and 90th percentiles. (B) Transcript abundance of intron-containing and intronless genes from (A) was compared. ****P≤0.0001, Mann-Whitney test. The dotted red line represents the median value. (C) Transcript abundance of expression-matched dataset, which consists only the subset of genes expressed within 50th to 75th percentile range. ns-not significant, Mann-Whitney test. The dotted red line represents the median value. (D-E) Cellular transcripts from expression-matched dataset were divided into intron-containing or intronless category and plotted against their fold-change value reflecting D10 activity in dox-inducible cells (D) or during infection (E). ****P≤0.0001, Mann-Whitney test. The whiskers represent the 10th and 90th percentiles.

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