Recorded and simulated signals under centromedian nucleus stimulation (CMS), and evolution of dynamic parameters of the model.

(A) 50Hz CMS (A1) No suppression of interictal activity in the recorded neocortical signal and in the simulated neocortical signal. (Stim ON: CMS period, N.U.: Normalized Units) (A2) Plastic parameter * depressed to 0.9921, peaked at 0.8871, peaked at 0.5333, and depressed to 0.2601, at 10 seconds (s), and then recovered. (B) 70Hz CMS (B1) Suppression of interictal activity was observed during CMS in the recorded neocortical signal and in the simulated neocortical signal, followed by a short plastic suppression of ~2 s. (B2) Plastic parameter * depressed to 0.9913, peaked at 0.9245, peaked at 0.7021, and depressed to 0.2553, at 10 s, and then recovered. (C) 100Hz CMS (C1) Suppression of interictal activity was observed during CMS in the recorded neocortical signal and in the simulated neocortical signal. A 15 s plastic suppression period was observed and simulated, following CMS. (C2) Plastic parameter * depressed to 0.9906, peaked at 0.9753, peaked at 0.9636, and depressed to 0.2414, at 10 s, and then recovered. (D) 150Hz CMS (D1) Suppression of interictal activity was observed during CMS in the recorded neocortical signal and in the simulated neocortical signal, followed by a short plastic suppression of ~2 s. (D2) The plastic parameters * became 0, became 0, became 0.9760 and became 0.2517, at 8.35 s; but then * recovered to 0.6597, recovered to 0.0302, peaked to 0.9998, and evolved to 0.0142, at 10 s. *: Plotted on a separate y-axis with a different scale.