Ratio of lysine to arginine in spike proteins of different coronaviruses compared to their predicted (scaled) solubility.

Dataset of viruses from the four genera of Orthocoronavirinae subfamily is the same as in Fig 4 in the main text. Scaled solubility was predicted from spike protein sequences using protein-sol [74]. Dashed line shows the predicted scaled solubility of 0 . 289, which is predicted to be the same for the entire dataset of SARS-CoV-2 spike protein sequences.

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