RING finger domains on A. thaliana groups.
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Three regions of multiple consensus sequences alignment from the 41 RING-H2 or the 49 RING-HC groups that encompass the residues involved in zinc ligation are displayed. The circled numbers indicate the residues involved in zinc ligation. The amino acid length of three regions from the RING finger domain is shown: five residues encompassing ligands 1 and 2; 14 to 17 residues from the central region encompassing ligands 3, 4, 5 and 6; and five residues encompassing ligands 7 and 8. The shaded blocks indicate common residues to most RING fingers; J corresponds to any hydrophobic residue. The location of proline residues previously described in ATL and BTL families is enclosed by a rectangle. The symbol * denotes regions that deviate in length from the canonical sequence (FHC01, two extra residues; FHC02, two extra residues; FHC03, two extra residues in 50% of the proteins; FCH10, three proteins show the canonical distances and two proteins show an extra residue between the 4th histidine and 5th cysteine; FHC21, two extra residues). The symbol ** represents the alignment denoting a substitution of one of the zinc ligation residues in all members of the family (FHH11, C to D; FHC05, C to H). The underscore indicates a gap within the alignment.