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Principle component analysis (PCA) graph of the differences in the gut microbial metagenomic compositions between the TLR5KO1 study and TLR5KO2 study.

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posted on 2016-03-07, 01:24 authored by Wei Zhang, Riley Hartmann, Hein Min Tun, Charles O. Elson, Ehsan Khafipour, W. Timothy Garvey

Metagenomic functions were predicted using 16S bacterial profile data implemented in PICRUSt pipeline and predicted KEGG functional genes (at level 3) were analyzed with Kruskal-Wallis H-test to generate PCA plot. Component 1 explains 93.5% of the variation, and component 2 explains 4.9% of the variation.

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Deletion of the Toll-Like Receptor 5 Gene Per Se Does Not Determine the Gut Microbiome Profile That Induces Metabolic Syndrome: Environment Trumps Genotype
PLOS ONEPLOS ONE

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TLR 5TLR 5KO TLR 5TLR 5KOtype micemicrobiota structuresyndromeTLR 5KO micelittermate TLR 5KOTLR 5KO microbiotaTLR 5 deficiencyInduces Metabolic Syndromelittermate controlshost gut microbiotatype 2 diabetesGut Microbiome ProfileEnvironment Trumps GenotypeTLR 5-deficient mouse modelToll-like receptorsgut microbiotainsulin resistanceToll-Like Receptor 5 Gene

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