Plateau potentials can be induced by mGlu receptors.

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posted on 2024-12-10, 18:29 authored by Nicholas Hagger-Vaughan, Daniel Kolnier, Johan F. Storm

A—Example traces showing the PP induced by tACPD. B—Summary plots of the PBD (i) and spikes (ii) following the application of tACPD. Both PBD (i) and post-burst spiking (ii) change significantly after wash-in of tACPD (WSR test, n = 12).

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“ global work transient receptor potential require external calcium pharmacological tests indicated persistent firing induced local calcium application hippocampal pyramidal cells depolarising plateau potentials cortical connections provide basal dendritic compartments (~ 50 μm 3 pyramidal cells probably essential also conscious brain states apical plateau potentials sustained depolarisations outlasting rat prefrontal cortex underlie working memory large apical dendrite div >< p cortical pyramidal neurons cell somatic recordings 3 pps depended 3 pps depend sustained activity suggested 2 +metabotropic cholinergic modulation working memory metabotropic cholinergic apical dendrite reverberant activity layer 2 considered essential conscious access prefrontal functions 3 non pps persisted apical l2 using whole soma ),range cortico profoundly altered prefrontal l2 output relationships key role generated independently executive functions architecture required

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Plateau potentials can be induced by mGlu receptors.

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