Phase modulation and insulin secretion.
(A) Glucose-dependent shape factor, s(G). Phase-modulated time traces of Ca2+ oscillations at 8 mM (green) and 15 mM (orange) glucose. (B) Insulin secretion (solid line), s(G)⋅r(G), decomposed into the shape factor, s(G), and amplitude (dotted line), r(G). The symbols represent experimental data from Bergsten  (square), Henquin  (circle), and Gylfe  (triangle). The insulin secretion is normalized to have a maximal value at 20 mM glucose.